OTC vs. Rx Retinol

November 24, 2019

Why do some skincare products require a prescription and others do not? We are here to help you understand the differences between common OTC retinol and prescription retinol. 


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First of all, it’s important that you know some over-the-counter (OTC) products are held to higher quality standards (technology, delivery systems, manufacturing) similar to the high standards of prescriptions (Rx). Most of the products we carry at LDG are ONLY dispensed in a physician’s office and are a “Cosme-ceutical”, which is a marriage of a cosmetic and pharmaceutical. The term is not a legal one, but it represents that what we dispense is really somewhere between an OTC product and a Rx.

A COSMETIC is defined as a product that is, “intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body’s structure or functions.” Most OTC skincare products available at Drug Stores fall into this category. 

The legal difference between a cosmetic skincare PRODUCT vs. a skincare DRUG is the product’s intended use. 

Drugs are “a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect.”



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To help you better understand these differences, let’s use Retinol as an example…

Retinol is a drug, both OTC and Rx, but most certainly not all retinol products are created equal. 

At Legacy Dermatology Group we sell an Advanced Retinol Serum that is 0.5% Pure Retinol. This product is not prescription and available OTC or online. Dr. Legacy and her team selected this Retinol because it’s backed by science, effective, helps diminish the signs of aging, minimizes irritation, and it’s elegant. The elegance of the product means it has added benefits like moisturizers and skin brightening serums; characteristics that make it stand out from prescription products.

Prescription Retinol is designed to do one thing: be effective. The appearance and feel might be grittier and more irritating to the skin. Also, prescription retinoids can have a much higher concentration of the active ingredient. 

Ultimately, when deciding on Rx vs. OTC, it really just depends on what your skincare needs are and that’s why it’s so important to work hand-in-hand with a board certified dermatologist! At LDG, we pride ourselves on being a lifestyle dermatology practice, addressing your concerns at every age. 

Still have questions? Email us!

Check out our ONLINE STORE for all LDG recommended products.

Source: Modern Aesthetics, May/June 2019